Recent developments in understanding the relationship between 22q11.2 deletion syndrome and psychosis

Purpose of reviewIndividuals with 22q11.2 deletion syndrome have high rates of comorbid mental illness, particularly psychosis and schizophrenia. The purpose of this review is to summarize recent research in the area of 22q11.2 deletion syndrome and psychosis.Recent findingsResearch over the[…]

Disrupted epigenetics in the Sotos syndrome neurobehavioral phenotype

Purpose of reviewSotos syndrome is among a growing list of disorders resulting from mutations in epigenetic machinery genes. These Mendelian disorders of the epigenetic machinery (MDEMs) exhibit phenotypic overlap broadly characterized by intellectual disability and atypical growth and behaviors. Manifestations[…]

Editorial introductions

No abstract available

Importance of Variable Selection in Multimodal Prediction Models in Patients at Clinical High Risk for Psychosis and Recent Onset Depression—Reply

In Reply We thank the authors for their interest in our Original Investigation published in JAMA Psychiatry. Nelson et al raised a query that our analysis was biased toward advocating structural magnetic resonance imaging for the prediction of functional outcomes[…]

March 2019 Highlights